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KMID : 0380020200350020169
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Korean Journal of Biotechnology and Bioengineering
2020 Volume.35 No. 2 p.169 ~ p.177
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Development of Superporous Interpenetrating Polymer Network Hydrogel Containing Sapogrelate Hydrochloride
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Lee Gye-Won
Boo So-Jeong
Lee Soo-Hwan
Cho Young-Ho
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Abstract
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In this study, superporous interpenetrating chitosan network hydrogel containing sapogrelate hydrochloride were prepared by changing the content of second polymer (polyvinyl alcohol, L-PVA) and crosslinking agent (formaldehyde, FA) and gas blowing agent (sodium bicarbonate, NaHCO3) using freezing (?80oC, 3 hr)-thawing (25oC, 4 hr)/gas blowing technique. The purpose of this study is to evaluate swelling and dissolution behavior for application as a gastroretensive drug delivery and optimize the formulation of superporus interpenetrating polymer network hydrogel (SPH-IPN) based on the design of experiment (DoE) using central composite design. Swelling ratio was highly dependent on the extent of cross-linking. Apparent density was dependent on the volume of the SPH-IPN and decreased with increasing crosslinking density. By the results we could confirm that the mechanism of drug release from hydrogel is Highchi and Korsmeyer-Peppas model by non-fickian diffusion. Optimized SPH-IPN (L-PVA 131.17%, FA 148.41%, NaHCO3 11.70%) showed satisfactory results for dependent variables. These studies showed the application of quality by design (QbD) in formulation development of chitosan-based SPH-IPN containing sapogrelate hydrochloride, which can be used as a sustain released gastroretentive drug delivery system in view of their swelling characteristics in acidic pH.
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KEYWORD
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superporus interpenetrating polymer network hydrogel, quality by design (QbD), freezing-thawing/gas blowing method, sapogrelate hydrochloride, central composite design
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